eProd Tangential Flow Filtration

Automated tangential flow filtration for concentration, diafiltration and buffer exchange, with TMP and ΔP control.

eProd TFF is a tangential flow filtration platform designed for industrial concentration, clarification and/or buffer exchange operations using diafiltration, with a high level of automation. This version integrates a stainless steel tank, online instrumentation and a control system PLC + HMI/eSCADA that allows operation with control strategies based on TMP, flow rate and pressure limits (ΔP), as well as recipes, traceability and reporting.

The system is compatible with different membrane formats (cassette, hollow fibre and, optionally, ceramic/tubular modules) and can cover microfiltration, ultrafiltration and nanofiltration* processes depending on the membrane and housing installed.

* Nanofiltration depends on the availability of modules/membranes in the selected format and their compatibility with the housing.

Compatible membrane formats, cassettes, hollow fibre and ceramic/tubular

The ePROD TFF platform is designed to support different TFF membrane formats within the same workflow, including cassettes, hollow fibre, and ceramic/tubular, depending on the selected membrane and housing. This flexibility helps match the setup to your process needs for concentration and diafiltration without changing the control approach.

Approximate operating ranges

The following ranges are indicative and should always be validated with the membrane manufacturer and through process testing. The recommended strategy is to work with TMP and ΔP limits and adjust the crossflow to control fouling and shear.

Filtration type (TFF)	Typical target	TMP guideline	Indicative flux (LMH)	Selection notes
Microfiltration	Clarification / turbidity reduction	0.1–1.0 bar	50–200	Select by pore size (µm). Pre-filtering can help stabilise the flux.
Ultrafiltration	Concentration / diafiltration	0.2–2.0 bar	5–80	Select by MWCO (kDa). Control by TMP and ΔP limits to reduce compaction risk.
Nanofiltration	Fractionation / low molecular weights	TBD (depending on module)	TBD	NF often requires higher pressures. Confirm housing compatibility and operating limits.

eProd Tangential Flow Filtration

Automated tangential flow filtration for concentration, diafiltration and buffer exchange, with TMP and ΔP control.

* Nanofiltration depends on the availability of modules/membranes in the selected format and their compatibility with the housing.

Flexibility across TFF membrane formats

Scale from pilot to production with a TFF workflow that keeps control logic, operating windows and data handling consistent, so concentration and diafiltration stay predictable as volumes increase.

• Concentration and diafiltration of biomolecules
• Clarification and turbidity reduction
• Buffer exchange (diafiltration at constant or variable volume)
• Processes with traceability, control and reporting requirements
• Separation processes with specific membranes

Advanced automation

Operating modes (concentration, diafiltration, CIP/SIP, etc.), recipes, user management and reporting.

Process control based on critical variables

Multi-purpose hygienic design

Scalability

Flexibility of membrane formats

Connectivity and data

Control modules included

As standard, the platform integrates control modules for TMP configuration, concentration mode, diafiltration mode, water flow test, filling, level control, CIP, SIP, advanced eSCADA, OPC server, user management, recipe management, reporting and functions aligned with 21 CFR Part 11.

Block	Standard	Optional
Tank and hygienic construction	MU tank (100 L or 500 L) in AISI 316L, self-draining conical bottom, hygienic connections; double-walled jacket for thermal management.	Special finishes (electropolishing/specific roughness), special elastomers, customised connections.
Membrane / housing format	Compatibility with cassette or hollow fibre formats (defined in the configuration supplied).	Ceramic/tubular; specific adapters/housings; NF-oriented configuration (subject to feasibility).
Pumps and hydraulic circuit	Twin-screw sanitary main pump for recirculation/crossflow; auxiliary pumps for addition and services (depending on version).	Lobular pump (alternative); additional high-flow pump for permeate/DF; special configurations for sensitive products.
Instrumentation and control of critical variables	Pressure measurement for TMP and ΔP calculation; flow meters; temperature; level/weight; alarms and interlocks.	Additional in-line sensors (pH, conductivity, turbidity, etc.), PAT integration.
Automation, HMI and data	PLC + HMI (control tower) and eSCADA: operating modes, recipes, user management, data logging, trends and reports; data export.	Advanced data integrity packages (extended audit trail, electronic signatures, hardening), remote access/VPN, specific IT/OT integration (OPC, etc.).
Cleaning and sterilisation	Integrated CIP (spray balls and sequences); SIP compatibility depending on configuration.	Extended SIP/specific ports; cleaning validation; dedicated utilities (external thermal skid).
Documentation and validation	Standard delivery documentation (manuals, diagrams, component lists, FAT according to scope).	Extended GMP packages (3.1 certificates, roughness, traceability), IQ/OQ upon request.

In addition to the options listed, the platform can be engineered to specific process, integration or GMP requirements. For a detailed list, see Section 10.

Selection of membrane format and housings cassette, hollow fibre, ceramic/tubular.
Alternative pumps (lobular) or high-flow auxiliary pumps for permeate/diafiltration.
Additional instrumentation (pH, conductivity, turbidity, UV, etc.) and PAT integration.
Advanced data and integrity packages (extended audit trail, electronic signatures, remote access).
Documentation and validation (IQ/OQ under proposal) and special finishes (electropolishing, roughness).

Features of eProd TFF 100 L and 500 L models

The platform is offered with two multi-purpose tank configurations. In terms of characteristics, the tanks are equivalent; the main difference is the volume and, consequently, the typical flow/area range and installed power.

Total Volumes

Useful volume	Total volume	Material in contact	Jacket	Notes
100 L	≈130 L	AISI 316L	Double wall (thermal management) AISI 304	Self-draining conical bottom; magnetic stirring; CIP/SIP (depending on version).
500 L	≈563 L	AISI 316L	Double wall (thermal management) AISI 304	Self-draining conical bottom; magnetic stirring; 3 CIP balls; SIP equipped.

Note: total volumes are reference values. For projects, confirm with current plan/layout.

Dimensional data

Membrane formats

Microfiltration, ultrafiltration and nanofiltration

Filter surface area range

Pumps

Software

Optional features and common configurations

The platform can be configured to suit different processes and regulatory requirements. Frequently used options are listed below:

Membrane format: cassette / hollow fibre / ceramic-tubular (depending on feasibility).
Filtration surface area expanded to ~64 m² (subject to engineering).
Lobular pump (alternative to twin-screw) for shear-sensitive products.
High-flow external pump for permeate/diafiltration (if high LMH is required).
Optional in-line sensors: pH, conductivity; PAT integration.
GMP documentation packages: 3.1 certificates, roughness, traceability; calibration plan.
Data integrity functions (21 CFR Part 11 / EU Annex 11) depending on configuration.
Special surface finishes (e.g. electropolishing) according to specification.
IQ/OQ (optional) upon request.

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Model	Overall dimensions (L×W×H)	Approximate mass	Remarks
100 L	2778 × 1605 × 2391 mm (enclosure without hoses)	Up to ≈1520 kg (installation)	Typical values; confirm according to version.
500 L	2778 × 1605 × 2391 mm (enclosure without hoses)	Tank ≈520 kg Secondary skid ≈380 kg	Skid enclosure equivalent to MU 100 L; confirm according to version.

Format	Typical uses	Advantages	Limitations/notes	Availability
Cassette (plates)	MF / UF / (NF*)	High surface area per footprint; scaling by number of cassettes; wide range of MWCO/porosity.	Requires compression and tightening torque; consumable; respect manufacturer's limits.	Cassette version (standard).
Hollow fibre	MF / UF / (NF*)	Low holdup; good hydraulic robustness; scaled by area.	Fouling depends on product; cleaning conditioned by membrane.	Hollow fibre version (standard).
Ceramic / tubular	MF / UF / (NF*)	High chemical/thermal resistance; allows aggressive cleaning; long service life.	Requires specific housing and hydraulic review (flow rate, ΔP) and CIP/SIP compatibility.	Optional (subject to feasibility).

Configuration	Cassette (m²)	Hollow fibre (m²)	Ceramic/tubular (m²)	Notes
MU platform 100–500 L (typical)	5–40	5–40	TBD	Typical standard range.
MU 500 L (example/reference)	6.84–34.2	12.1–36.3	TBD	Nominal ranges depending on version/housing.
Extension (optional under engineering)	Up to ~64	Up to ~64 (depending on module)	TBD	Hydraulic validation required.

Service	Standard type	Optional type	Typical capacity (reference)	Notes
Recirculation / filtration (crossflow)	Sanitary screw (twin-screw)	Sanitary lobular	Up to ~14 m³/h (100 L, ref.) Up to ~30 m³/h @ 2 barg (500 L, ref.)	VFD control. Selection based on viscosity and shear sensitivity.
Diafiltration / buffer addition	Peristaltic	—	Typical 0.6–45 L/min (depending on tubing)	Addition control by flow rate or mass, according to DF strategy.
Permeate control	Peristaltic (depending on version)	High-flow external pump	Depending on configuration (e.g. up to 16 L/min with ID 17 mm in external option)	Recommended when high permeate flow (LMH) is required.
CIP / transfers	Sanitary centrifuge	—	Up to ~5 m³/h @ ~3.6 barg (ref.)	For recirculation of cleaning solutions and/or transfers.

Area	Operating modes (included)	Purpose
Filtration	TMP configuration, concentration, diafiltration	Run standard TFF workflows with TMP and ΔP-based strategies.
Checks	Water flow test	Reference test and basic verification of hydraulic performance.
Handling	Filling, level control	Support safe operation and controlled tank management.
Cleaning / sterilisation	CIP, SIP	Execute cleaning and (when applicable) sterilisation sequences with traceability.

Mode	Element	Working pressure (bar[g])	Working pressure (psi[g])	T max (°C / °F)
Process	Vessel	0 / +2.5	0 / +36.3	+90 / 194
Process	Jacket	0 / +3.8	0 / +55.1	+90 / 194
Sterilisation	Vessel	0 / +2.5	0 / +36.3	+130 / 266
Sterilisation	Jacket	0 / +3.8	0 / +55.1	+150 / 302

Working volume	MU (Cell culture), reference	MB (Microbial), reference
10 L	0 to 300 rpm	0 to 1000 rpm
20 L	0 to 250 rpm	0 to 1000 rpm
30 L	0 to 200 rpm	0 to 1000 rpm
50 L	0 to 180 rpm	0 to 1000 rpm

Parameter	Typical value	Notes
Quantity	4 units (integrated)	In control tower; assignment defined by configuration
Speed	0-300 rpm	Variable control from eSCADA
Minimum flow	0-10 mL/min	Example with 0.8 mm ID tubing; depends on tubing and calibration
Maximum flow	Up to ~366 mL/min	Example with 4.8 mm ID tubing; actual flow depends on calibration
Operating modes	OFF / AUTO / MANUAL / PROFILE	AUTO typically associated to pH/DO/foam loops or recipe
Functions	PURGE, calibration, totaliser, PWM	PWM available for low flow setpoints below minimum operating level

Working volume (L)	VVM min	VVM max	Air (L/min)	O2 (10%) (L/min)	CO2 (20%) (L/min)	N2 (10%) (L/min)
10	0.5	1.5	5-15	0.5-1.5	1-3	0.5-1.5
20	0.5	1.5	10-30	1-3	2-6	1-3
30	0.5	1.5	15-45	1.5-4.5	3-9	1.5-4.5
50	0.5	1.5	25-75	2.5-7.5	5-15	2.5-7.5

eProd Tangential Flow Filtration

Compatible membrane formats, cassettes, hollow fibre and ceramic/tubular

Approximate operating ranges

eProd Tangential Flow Filtration

Flexibility across TFF membrane formats

Advanced automation

Process control based on critical variables

Multi-purpose hygienic design

Scalability

Flexibility of membrane formats

Connectivity and data

Control modules included

Features of eProd TFF 100 L and 500 L models

Total Volumes

Dimensional data

Membrane formats

Microfiltration, ultrafiltration and nanofiltration

Filter surface area range

Pumps

Software

Optional features and common configurations

Send us a message for a generic quote.

Cellular configuration

Cellular configuration

Cellular configuration

Microbial configuration

Technical specifications

Materials and finishes

Design conditions

Pressure control and safeguards

Agitation

Integrated peristaltic pumps (additions)

Gas flow control (microbial reference capacity)

Instrumentation and sensors

Automation, software and connectivity

Utilities

Compliance and deliverables

Ordering and configuration

Cellular configuration

Technical specifications

Cellular configuration

Technical specifications

Models and working volumes

Design conditions and operating limits

Materials and finishes

Agitation system

Weighing and volume control

Pumps and fluid handling

Thermal management (optional jacket)

Instrumentation and sensors

Automation, software and data

Utilities and facility interfaces

Documentation and deliverables

Ordering and configuration

Operating windows microbial vs. cell culture

Indicative operating windows for cellular and microbial processes. Final values depend on bag configuration, impellers, aeration strategy and process targets.

Typical gas line ranges by model and application. Installed ranges and gas setup depend on selected options and project scope.